The present study refers to the synthesis of new antidepressant candidates using the pyrazoline scaffold. In an\nattempt to identify potential lead antidepressant agents, a number of N-((3-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-\n1-yl)methyl)-substituted amine (mannich base) were synthesized by microwave assisted synthesis. The antidepressant activity\nof the synthesized compounds (3aââ?¬â??3h) was evaluated by forced swim test (FST) and tail suspension test (TST). The present\nwork showed significant antidepressant activity for all compounds, of the series compounds (3e) and (3g) were found to be\npotent molecules of this series when compared with the reference drugs imipramine and fluoxetine. Thus, these compounds can\nserve as potential leads for further antidepressant studies.
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